产品类型：siRNA套装（3保1）

目的基因：Homo sapiens vitamin D receptor (VDR), transcript variant 1, mRNA NM_000376

产品组成：3条siRNA + NC对照

产品规格：各提供2OD即5nmol（NC对照提供0.5OD）

干扰效率：保证其中至少一条siRNA干扰效率大于70%

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This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.