rAd-AQP4
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rAd-AQP4

产品货号：HG-rAd001650
产品类型：Human
基因信息：Homo sapiens aquaporin 4 (AQP4), transcript variant a, mRNA
出货周期：现货
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产品概述
基因简介
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产品概述
产品名称rAd-AQP4产品类型Human
产品货号HG-rAd001650基因信息Homo sapiens aquaporin 4 (AQP4), transcript variant a, mRNA
NCBI序列号NM_001650出货周期现货
基因简介

This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. 

亚单位结构: Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1.
 
结构域: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
亚细胞定位: Membrane; Multi-pass membrane protein.
 
组织特异性: Brain - muscle >> heart, kidney, lung, and trachea.
 
 
翻译后修饰: Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40% (By similarity).
 
相似的序列: Belongs to the MIP/aquaporin (TC 1.A.8) family.
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